The UK government announced the measure on Tuesday morning, but the challenge trial won’t start until some point in early 2021 AND Experimental coronavirus vaccines: When they will roll out, side effects and what it all means for you

https://bgr.com/2020/10/21/coronavirus-vaccine-challenge-trial-uk/

The UK government announced the measure on Tuesday morning, but the challenge trial won’t start until some point in early 2021.

By then, some of the COVID-19 vaccine frontrunners will have published their final results for Phase 3 trials, including #AstraZeneca, #Moderna, and #Pfizer.

Some will say that a challenge trial might not be needed considering that Pfizer estimates it will have results in about a month.

Not to mention that the coronavirus is surging in the US and Europe, so there’s likely more than enough exposure for regular Phase 3 trials to proceed.

[“Some will say that a #challenge trial might not be needed” - U won’t see me getting jabbed unless I know for certain a #challenge trial was conducted]

+++

https://www.cleveland.com/coronavirus/2020/10/experimental-coronavirus-vaccines-when-they-will-roll-out-side-effects-and-what-it-all-means-for-you.html

Experimental coronavirus vaccines: When they will roll out, side effects and what it all means for you

What are the drawbacks?

Volunteers in the AstraZeneca trials said they felt some pain in the area where they received the injection, mild fever, muscle aches and chills, according to a paper published in the Lancet in July.

Five participants in various parts of the country — three in Moderna’s study and two in Pfizer’s trials — recently told CNBC that they experienced severe chills, high fever, body aches, bad headaches and exhaustion after receiving the shots.

Researchers are paying close attention to unexpected side effects, especially any that lead to hospitalizations, Malvestutto said.

“There’s almost no chance the vaccine will work on 100% of people,” which is true of all vaccines, said Dr. Tim Chan, director of the Center for Immunotherapy and Precision Immuno-Oncology at the Cleveland Clinic.

Older people, who have a lowered ability to produce antibodies, as well as people at high-risk for COVID-19, may need to take a combination of COVID-19 vaccines, Chan said.

Future studies will be needed to determine if these people will need a combination of the vaccines currently in development, or if a second generation of COVID-19 vaccines will be needed to protect them, Chan said.

[#challenge trials - vaccinated are challenged with live (wild) virus; in the past those who’d been vaccinated did much worse than the unvaccinated, that’s why challenge trials so important]

#SARSCoV2