https://cen.acs.org/pharmaceuticals/vaccines/Adenoviral-vectors-new-COVID-19/98/i19
In the early 2000s, Wilson’s lab at Penn began hunting for chimpanzee adenoviruses, which the researchers isolated from the animal’s feces.
“Chimpanzees are very protected, but stools can be easily collected,” says Stefano Colloca, who worked on adenoviral vectors at Merck Research Laboratories’ center in Rome in the early 2000s.
In 2012, the #Oxford group developed its own chimpanzee-derived vector, dubbed ChAdOx1, based on an adenovirus discovered in chimpanzee feces.
In July, Okairos, which has since morphed into a company now called ReiThera, plans to start a clinical trial of its own COVID-19 vaccine, which is based on an adenovirus discovered in gorilla feces.
The biggest drawback to the great-ape adenoviral vector vaccines may be their lack of prior testing in humans.
Before the coronavirus pandemic, Oxford’s ChAdOx1 vector had been given to only about 320 people, and ReiThera’s new gorilla-derived vector has never been tested in humans.
[“It’s 11 o’clock, do you know from where your vaccine is derived?”]
Keywords: adenovirus derived vaccine chimpanzee gorilla feces covid-19 sars-cov-2
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Conversely ...
https://www.healio.com/news/pulmonology/20200721/inhaled-interferon-beta-shows-promise-for-severe-covid19
Interferon beta is a naturally occurring protein that orchestrates the body’s antiviral responses.
SNG001 is a formulation of IFN-beta-1a for direct delivery to the lungs via nebulization.
#SARSCoV2
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